Instituto Oswaldo Cruz - Ciência e Saúde desde 1900

Área de PDI em Doença de Chagas 2010

Adesse D, Iacobas DA, Iacobas S, Garzoni LR, Meirelles Mde N, Tanowitz HB, Spray DC. Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi. Am. J. Trop. Med. Hyg.. 2010 May;82(5):846-54.

Adesse D, Lisanti MP, Spray DC, Machado FS, Meirelles MD, Tanowitz HB, Garzoni LR. Trypanosoma cruzi infection results in the reduced expression of caveolin-3 in the heart. Cell Cycle. 2010 Apr 10;9(8).

Andrade LO, Galvão LM, Meirelles Mde N, Chiari E, Pena SD, Macedo AM. Differential tissue tropism of Trypanosoma cruzi strains: an in vitro study. Memórias do Instituto Oswaldo Cruz. 2010 Sep;105(6):834-7.

Batista Dda G, Batista MM, de Oliveira GM, do Amaral PB, Lannes-Vieira J, Britto CC, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Boykin DW, Soeiro Mde N. Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas disease treatment. Antimicrob Agents Chemother. 2010 Jul; 54(7):2940-52. Epub 2010 May 10.

Batista DG, Pacheco MG, Kumar A, Branowska D, Ismail MA, Hu L, Boykin DW, Soeiro MN. Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi. Parasitology. Journal Cambridge. 2010 Feb;137(2):251-9. Epub 2009 Sep 21.

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Batista DGJ, da Silva PB, Lachter DR, Silva RS, Aucelio RQ, Louro SRW, Beraldo H, Soeiro MNC, Teixeira LR. Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi. Polyhedron. 2010, Volume 29, Issue 10, Pages 2232-2238

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Caiaffa CD, Stiebler R, Oliveira MF, Lara FA, Paiva-Silva GO, Oliveira PL. Sn-protoporphyrin inhibits both heme degradation and hemozoin formation in Rhodnius prolixus midgut. Insect Biochem Mol Biol. 2010 Dec; 40: 855-860.

Campos MC, Salomão K, Castro-Pinto DB, Leon LL, Barbosa HS, Maciel MA, de Castro SL. Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi. Parasitol Res. 2010 Oct;107(5):1193-204. Epub 2010 Aug 3.

Capriles PV, Guimarães AC, Otto TD, Miranda AB, Dardenne LE, Degrave WM. Structural modelling and comparative analysis of homologous, analogous and specific proteins from Trypanosoma cruzi versus Homo sapiens: putative drug targets for Chagas disease treatment. BMC Genomics. 2010 Oct 29;11:610.

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Carbajal de la Fuente AL, Cunha V, Rocha N, Lopes CM, Noireau F. Comparative biology of the two sister species of Triatominae (Hemiptera: Reduviidae). Rev. Soc. Bras. Med. Trop. 2010 Feb;43(1):15-8.

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Cestari I, Ramirez MI. Inefficient complement system clearance of Trypanosoma cruzi metacyclic trypomastigotes enables resistant strains to invade eukaryotic cells. PLoS One. 2010 Mar 16;5(3):e9721.

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Da Silva CF, da Silva PB, Batista MM, Daliry A, Tidwell RR, Soeiro Mde N. The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi. Mem Inst Oswaldo Cruz. 2010 May;105(3):239-45.

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Da Silva EN Jr, Guimarães TT, Menna-Barreto RF, Pinto Mdo C, de Simone CA, Pessoa C, Cavalcanti BC, Sabino JR, Andrade CK, Goulart MO, de Castro SL, Pinto AV. The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-lapachone-based 1,2,3-triazoles. Bioorg Med Chem. 2010 May 1;18(9):3224-30. Epub 2010 Mar 16.

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Deolindo P, Teixeira-Ferreira AS, DaMatta RA, Alves EW. L-amino acid oxidase activity present in fractions of Bothrops jararaca venom is responsible for the induction of programmed cell death in Trypanosoma cruzi. Toxicon. 2010 Nov;56(6):944-55. Epub 2010 Jul 6.

De Melo Medeiros M, Araújo-Jorge TC, Batista WS, da Silva TM, de Souza AP. Trypanosoma cruzi infection: Do distinct populations cause intestinal motility alteration? Parasitol Res. 2010 Jun;107(1):239-42. Epub 2010 May 8.

De Souza AP, Sieberg R, Li H, Cahill HR, Zhao D, Araújo-Jorge TC, Tanowitz HB, Jelicks LA. The role of selenium in intestinal motility and morphology in a murine model of Trypanosoma cruzi infection. Parasitol Res. 2010 May;106(6):1293-8. Epub 2010 Feb 27.

De Souza EM, Nefertiti AS, Bailly C, Lansiaux A, Soeiro MN. Differential apoptosis-like cell death in amastigote and trypomastigote forms from Trypanosoma cruzi-infected heart cells in vitro. Cell Tissue Res. 2010 Jul;341(1):173-80. Epub 2010 May 22.

Ennes-Vidal V, Menna-Barreto RF, Santos AL, Branquinha MH, d'Avila-Levy CM. Effects of the calpain inhibitor MDL28170 on the clinically relevant forms of Trypanosoma cruzi in vitro. J Antimicrob Chemother2010 Jul;65(7):1395-8. Epub 2010 May 10.

Fampa P, Lisboa CV, Zahner V, Jansen AM, Ramirez MI. Wide proteolytic activity survey reinforces heterogeneity among Trypanosoma cruzi TCI and TCII wild populations. Vector Borne Zoonotic Dis. 2010 Nov;10(9):839-45. Epub 2010 Apr 26.

Fampa P, Santos AL, Ramirez MI. Trypanosoma cruzi: ubiquity expression of surface cruzipain molecules in TCI and TCII field isolates. Parasitol Res. 2010 Jul;107(2):443-7. Epub 2010 May 30.

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Freitas SP, Gonçalves TC, Serrão JE, Costa J, Santos-Mallet JR. Male reproductive system structure and accessory glands ultrastructure of two species of Triatoma (Hemiptera, Reduviidae, Triatominae). Micron. 2010 Jul;41(5):518-25. Epub 2010 Feb 11.

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Garcia ES, Castro DP, Figueiredo MB, Azambuja P. Immune homeostasis to microorganisms in the guts of triatomines (Reduviidae): A Review. Mem Inst Oswaldo Cruz. 2010 Aug;105(5):605-10. Review.

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Garcia ES, Genta FA, de Azambuja P, Schaub GA. Interactions between intestinal compounds of triatomines and Trypanosoma cruzi. Trends Parasitol. 2010 Oct;26(10):499-505. Review.

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Genta FA, Souza RS, Garcia ES, Azambuja P. Phenol oxidases from Rhodnius prolixus: Temporal and tissue expression pattern and regulation by ecdysone. J Insect Physiol. 2010 Sep;56(9):1253-9. Epub 2010 Apr 7.

Guedes PM, Oliveira FS, Gutierrez FR, da Silva GK, Rodrigues GJ, Bendhack LM, Franco DW, Do Valle Matta MA, Zamboni DS, da Silva RS, Silva JS. Nitric oxide donor trans-[RuCl([15]aneN4)NO]2+ as a possible therapeutic approach for Chagas´ disease. Br J Pharmacol. 2010 May;160(2):270-82. Epub 2010 Jan 27.

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Guedes PM, Veloso VM, Talvani A, Diniz LF, Caldas IS, Do-Valle-Matta MA, Santiago-Silva J, Chiari E, Galvão LM, Silva JS, Bahia MT. Increased type 1 chemokine expression in experimental Chagas disease correlates with cardiac pathology in Beagle dogs. Vet Immunol Immunopathol. 2010 Nov 15;138(1-2):106-13. Epub 2010 Jun 19.

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Kikuchi SA, Sodré CL, Kalume DE, Elias CG, Santos AL, de Nazaré Soeiro M, Meuser M, Chapeaurouge A, Perales J, Fernandes O. Proteomic analysis of two Trypanosoma cruzi zymodeme 3 strains. Exp Parasitol. 2010 Dec;126(4):540-51. Epub 2010 Jun 8.

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Menna-Barreto RF, Beghini DG, Ferreira AT, Pinto AV, De Castro SL, Perales J. A proteomic analysis of the mechanism of action of naphthoimidazoles in Trypanosoma cruzi epimastigotes in vitro.J Proteomics. 2010 Nov 10;73(12):2306-15. Epub 2010 Jul 16.

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Monteiro RV, Dietz JM, Jansen AM. The impact of concomitant infections by Trypanosoma cruzi and intestinal helminths on the health of wild golden and golden-headed lion tamarins. Res Vet Sci. 2010 Aug;89(1):27-35. Epub 2010 Feb 11.

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Nogueira de Melo AC, de Souza EP, Elias CG, dos Santos AL, Branquinha MH, d'Avila-Levy CM, dos Reis FC, Costa TF, Lima AP, de Souza Pereira MC, Meirelles MN, Vermelho AB. Detection of matrix metallopeptidase-9-like proteins in Trypanosoma cruzi. Exp Parasitol. 2010 Jul;125(3):256-63. Epub 2010 Feb 6.

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Olivieri BP, Molina JT, de Castro SL, Pereira MC, Calvet CM, Urbina JA, Araújo-Jorge TC. A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease. Int J Antimicrob Agents. 2010 Jul;36(1):79-83. Epub 2010 May 7.

Olivieri BP, Vasconcellos R, Nóbrega A, Minoprio P, Kaveri SV, Araújo-Jorge TC. Intravenous immunoglobulin increases survival time in the acute phase of experimental Chagas disease. Parasite Immunol. 2010 Jun;32(6):464-9.

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Oliveira TG, Carvalho-Costa FA, Gomes TF, Sarquis O, Sposina R, Lima MM. Developmental and reproductive patterns of Triatoma brasiliensis infected with Trypanosoma cruzi under laboratory conditions. Mem Inst Oswaldo Cruz. 2010 Dec;105(8):1057-60.

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Salomão K, de Souza EM, Carvalho SA, da Silva EF, Fraga CA, Barbosa HS, de Castro SL. In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi. Antimicrob Agents Chemother. 2010 May; 54 (5):2023-31. Epub 2010 Mar 15.

Salomão K, de Souza EM, Henriques-Pons A, Barbosa HS, de Castro SL.Brazilian green propolis: Effects in vitro and in vivo on Trypanosoma cruzi. Evid Based Complement Alternat Med. 2009 Mar 11.

Sarquis O, Carvalho-Costa FA, Oliveira LS, Duarte R, D Andrea PS, de Oliveira TG, Lima MM. J Ecology of Triatoma brasiliensis in northeastern Brazil: seasonal distribution, feeding resources, and Trypanosoma cruzi infection in a sylvatic population. Journal of Vector Ecology. 2010 Dec;35(2):385-94.

Silvério JC, de-Oliveira-Pinto LM, da Silva AA, de Oliveira GM, Lannes-Vieira J. Perforin-expressing cytotoxic cells contribute to chronic cardiomyopathy in Trypanosoma cruzi infection. Int J Exp Pathol. 2010 Feb;91(1):72-86. Epub 2009 Oct 28.

Souza AP, Jelicks LA, Tanowitz HB, Olivieri BP, Medeiros MM, Oliveira GM, Pires AR, Santos AM, Araújo-Jorge TC. The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice. Mem. Inst. Oswaldo Cruz. 2010 Sep;105(6):746-51.

Romanha AJ, Castro SL, Soeiro Mde N, Lannes-Vieira J, Ribeiro I, Talvani A, Bourdin B, Blum B, Olivieri B, Zani C, Spadafora C, Chiari E, Chatelain E, Chaves G, Calzada JE, Bustamante JM, Freitas-Junior LH, Romero LI, Bahia MT, Lotrowska M, Soares M, Andrade SG, Armstrong T, Degrave W, Andrade Zde A. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem. Inst. Oswaldo Cruz. 2010 Mar;105(2):233-8.

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