LABORATÓRIO DE BIOQUÍMICA EXPERIMENTAL E COMPUTACIONAL DE FÁRMACOS
ARTIGOS CIENTÍFICOS
Confira a lista dos artigos publicados em periódicos indexados pelos pesquisadores do Laboratório de Bioquímica Experimental e Computacional de Fármacos do Instituto Oswaldo Cruz (IOC/Fiocruz):
2014
Indexado (fator de impacto >=1 e < 2,71)
Bastos FF, Dantas RF, Tobar SA, da Cunha Bastos Neto J, da Cunha Bastos VL, Ziolli RL, Arruda MA 2014. Behaviour of the oxidant scavenger metallothionein in hypoxia-induced neotropical fish. Ecotox Environ Safe 103: 24-28.Dantas RF, Oliveira M E, Silva Jr FP, BARRETO L H, BURBANO R M, ABRAHIM-VIEIRA B, DE OLIVEIRA R, FERREIRA, V. F. , CUNHA, A. C. , BOECHAT F DA C, SOUZA, M C 2014. Synthesis, Cytotoxicity and Mechanistic Evaluation of 4-Oxoquinoline-3-carboxamide Derivatives: Finding New Potential Anticancer Drugs. Molecules 19: 6651-6670.
TSCHOEKE, D. A., NUNES, Gisele Lopes, Fonseca RJM, Oliveira, Joana, ROMÃO-DUMARESQ, ALINE , Gomes, M. R., Mattos L.P, Loureiro DR, STOCO, P. H., GUEDES, H. L. M, Miranda AB, RUIZ, J. C., Pitaluga NA, Silva Jr FPS, Probst CM, Dickens, N. J., Mottram, J. C., Grisard, E. C., Davila AMR 2014. The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite. Evol Bioinform 10: 131-153.
Indexado (fator de impacto >=2,71 e < 4,35)
Gonzaga D, Senger MR, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Silva Jr FPS 2014. 1-phenyl-1H- and 2-phenyl-2H-1,2,3-triazol derivatives: Design, Synthesis and Inhibitory Effect on alphaglycosidases. Eur J Med Chem 74: 461-476.Silva FR, Pego PN, De-Simone SG 2014. Identification of linear B epitopes of pertussis of Bordetela pertussis induced by immunization with whole and acellular vaccine. Vaccine 32: 6251-6258.
Menna-Barreto RFS, Belloze KT, Perales J, Silva Jr FPS 2014. Proteomic and Bioinformatic Analysis of Trypanosoma cruzi Chemotherapy and Potential Drug Targets: New Pieces for an Old Puzzle. Curr Drug Targets 15: 255-271.
Cardoso MF, Rodrigues PC, Moreira-de-Oliveira MEI, Gama IL, da Silva IM, Santos IO, Rocha IR, Pinho RT, Ferreirra VF, de Souza MC, da Silva F de C, Silva Jr FPS 2014. Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. Eur J Med Chem 84: 708-717.
2013
Indexado (fator de impacto >=1 e < 2,71)
Souza ALM, P. Diaz Dellavalle, Andre Cabrera, Paloma Larrañaga, Marco Dalla Riza, De-Simone SG 2013. Antimicrobial activity of pleurocidin activity is retained in PLC-2, a C-terminal 12-amino acid fragment. Toxicon 45: 78-84.
De-Simone SG, Pego PN, Pinto LALT, J.D.L. Santos, Tathiane Santos De Simone, Anibal R Melgarejo, Aniese Silva Aguiar, Daniela P Marchi Salvador 2013. Linear B-cell epitopes in BthTX-I, BthTX-II and BthA-I, phospholipase A2`s from Bothrops jararacussu snake venom, recognized by therapeutically neutralizing commercial horse antivenom.. Toxicon 72: 90-101.
Indexado (fator de impacto >=2,71 e < 4,35)
Carolina G Bottino, Gomes LP, Coura JR, David William Provance, De-Simone SG 2013. Chagas disease-specific antigens: characterization of epitopes in CRA/FRA by synthetic peptide mapping and evaluation by ELISA-peptide assay. BMC Infect Dis 13: - .
Neves AP, Pereira MX, Peterson EJ, Kipping R, Vargas M, Silva Jr FP, Carneiro JW, Farrell NP 2013. Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes. J Inorg Biochem 119: 54-64.
Silveira LB, Marchi-Salvador DP, Santos-Filho NA, Silva Jr FP, Marcussi S, Fuly AL, Nomizo AL, da Silva SL, Stábeli RG, Arantes EC, Soares AM 2013. Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A2 from Bothrops moojeni snake venom. J Pharmaceut Biomed 73: 35-43.
de Oliveira RB , Senger MR, Vasques LM, Gasparotto J, dos Santos JP, Pasquali MA, Moreira JC, Silva Jr FP, Gelain DP 2013. Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice. Int J Parasitol 43: 371-379.
Indexado (fator de impacto >=4,35 e < 7,51)
Silva Jr FPS, Montoya BOA 2013. On the three-finger protein domain fold and CD59-like proteins in Schistosoma mansoni. PLoS Neglect Trop D 7: - .
2012
Indexado (fator de impacto < 1 ou sem FI)
Cárdenas MQ, Fernandes BM, Justo MC, dos Santos AL, Cohen SC 2012. Helminth parasites of Ctenosciaena gracilicirrhus (Perciformes: Sciaenidae) from the coast of Angra dos Reis, Rio de Janeiro State, Brazil. Rev Mex Biodivers 83: 31-35.
Indexado (fator de impacto >=1 e < 2,71)
Santos CP, Santos AL, Cunha R, Chisholm LA 2012. A new species of Heterocotyle Scott, 1904 (Monogenea: Monocotylidae) from the gills of Dasyatis guttata (Dasyatidae) in southwestern Atlantic waters off Rio de Janeiro, Brazil. Syst Parasitol 81: 65-70.
Beghini DG, Ferreira AT, de Almeida VC, Caminha MA, Silva Jr FP, Perales J, Menna-Barreto RF 2012. New insights in Trypanosoma cruzi proteomic map: further post-translational modifications and potential drug targets in Y strain epimastigotes. JIOMICS 2: 106-113.
Indexado (fator de impacto >=2,71 e < 4,35)
Senger MR, Gomes LC, Ferreira SB, Kaiser CR, Ferreira VF, Silva FP Jr 2012. Kinetics studies on the inhibition mechanism of pancreatic alpha-amylase by glycoconjugated 1H-1,2,3-triazoles: A new class of inhibitors with hypoglycemiant activity. Chembiochem 13: 1584-1593.
Carreira JC, Machado da Silva AV, Pereira DP, Brazil RP 2012. Natural infection of Didelphis aurita (Mammalia: Marsupialia) with Leishmania infantum in Brazil. Parasit Vectors 5: - .
Martins VE, Alencar CH, Kamimura MT, de Carvalho Araújo FM, De Simone SG, Dutra RF, Guedes MI 2012. Occurrence of natural vertical transmission of dengue-2 and dengue-3 viruses in Aedes aegypti and Aedes albopictus in Fortaleza, Ceará, Brazil. PLoS One 7: - .
Trevizano LM, Ventorim RZ, de Rezende ST, Silva Jr FP, Guimarães VM 2012. Thermostability improvement of Orpinomyces sp. xylanase by directed evolution. J Mol Catal B-Enzym 81: 12-18.
2011
Falcão DQ, Santos AR, Ortiz-Silva B, Louro RP, Seiceira R, Finotelli PV, Ferreira JLP, de Simone SG, Amaral ACF. Development of nanoencapsulation forms from Cymbopogon citratus essential oil. Lat. Am. J. Pharm. 30 (4): 765-72 (2011).
Lima JC Jr, Jiang J, Rodrigues-da-Silva RN, Banic DM, Tran TM, Ribeiro RY, Meyer VS, De-Simone SG, Santos F, Moreno A, Barnwell JW, Galinski MR, Oliveira-Ferreira J. B cell epítope mapping and characterization of naturally acquired antibodies to the Plasmodium vivax merozoite surface protein-3alpha (PvMSP-3alpha) in malaria exposed individuals from Brazilian Amazon. Vaccine. 2011 Feb 17;29(9):1801-11. Epub 2011 Jan 6.
2010
Da Silva-López RE, dos Santos TR, Morgado-Diaz JA, Tanaka MN, de Simone SG 2010. Serine protease activities in Leishmania (Leishmania) chagasi promastigotes. Parasitol Res 107: 1151-1162.
Romero L, Marcussi S, Marchi-Salvador DP, Silva FPJr, Fuly AL, Stábeli RG, da Silva SL, González J, Monte AD, Soares AM 2010. Enzymatic and structural characterization of a basic phospholipase A(2) from the sea anemone Condylactis gigantea. Biochimie 92: 1063-1072.
Correa-Neto C, Teixeira-Araujo R, Aguiar AS, Melgarejo AR, De-Simone SG, Soares MR, Foguel D, Zingali RB 2010. Immunome and venome of Bothrops jararacussu: A proteomic approach to study the molecular immunology of snake toxins. Toxicon 55: 1222-1235.
Lima-Junior JC, Banic DM, Tran TM, Meyer VS, De-Simone SG, Santos F, Porto LC, Marques MT, Moreno A, Barnwell JW, Galinski M, Oliveira-Ferreira J 2010. Promiscuous T-cell epitopes of Plasmodium merozoite surface protein 9 (PvMSP9) induces IFN-gamma and IL-4 responses in individuals naturally exposed to malaria in the Brazilian Amazon. Vaccine 28: 3185-3191.
De Matos Guedes HL, Pinheiro RO, Chaves SP, De-Simone SG, Rossi-Bergmann B 2010. Serine proteases of Leishmania amazonensis as immunomodulatory and disease-aggravating components of the crude LaAg vaccine. Vaccine 28: 5491-5496.
Ferreira SB, Sodero AC, Cardoso MF, Lima ES, Kaiser CR, Silva FP Jr, Ferreira VF 2010. Synthesis, biological activity, and molecular modeling studies of 1H-1,2,3-triazole derivatives of carbohydrates as alpha-glucosidases inhibitors. J Med Chem 53: 2364-2375.
2009
Pinho RT, Beltramini LM, Alves CR, De-Simone SG. Trypanosoma cruzi: Isolation and characterization of aspartyl proteases. Experimental Parasitology.2009 Jun;122(2):128-33.
Horta BAC, Sodero ACR, de Alencastro RB. Investigating the differential activation of vascular endothelial growth factor (VEGF) receptors. Journal of Molecular Graphics & Modelling. 2009 Oct;28(3):287-96.
2008
Silva Jr FPS, Guedes HLM, Correa_Netto C, Salles CM, Alexandre G, Oliveira CL, Torriani I, De-Simone SG 2008. Structural characterization and low-resolution model of BJ-48, a thrombin-like enzyme from Bothrops jararacussu venom. Biophys Chem 132: 159-164.
Guimarães AJ, Hamilton AJ, Guedes HLM, Nosanchuk JD, Zancopé-Oliveira RM 2008. Biological function and molecular mapping of M antigen in yeast phase of Histoplasma capsulatum. PLoS One 3.
Lima-junior JC, Tran TM, Meyer EVS, Singh B, De-Simone SG, Santos F, Daniel-Ribeiro CT, Moreno A, Barnwell JW, Galinski MR, Oliveira-Ferreira J 2008. Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals. Vaccine 26: 6645-6654.
2007
Silva Jr FPS, Guedes HLM, Garvey LC, Aguiar AS, Bourguignon SC, Di Cera E, De-Simone SG 2007. BJ-48, a novel thrombin-like enzyme from the Bothrops jararacussu venom with striking specificity for Arg over Lys in P1: Role of N-glycosylation in thermostability and active site accessibility. Toxicon 50: 18-31.
Silva-Lopez RE, Diaz JM, De-Simone SG 2007. Effects of serine protease inhibitors on viability and morphology of Leishmania (Leishmania) amazonensis promastigotes. Parasitol Res 101: 1627-1635.
Salles CM, Gagliano P, Leitão SAT, Salles JB, Guedes HLM, Cassano VPF, De-Simone SG 2007. Identification and characterization of proteases from skin mucus of tambacu, a Neotropical hybrid fish. Fish Physiol Biochem 33: 173-179.
Guedes HLM, Resende Neto JM, Fonseca MA, Salles CMC, Rossi-Bergman B, De-Simone SG 2007. Identification of serines protease from Leishmania braziliensis. Z Naturforsch C 62c: 373-381.
Guedes HLM, Carneiro MPD, Gomes DCO, Rossi-Bergman B, De-Simone SG 2007. Oligopeptidase B from Leishmania amazonensis: molecular cloning, gene expression analysis and molecular model. Parasitol Res 101: 853-863.
2006
De-Simone SG, Salles CM, Silva CMB, Voloch AH 2006. Purification and amino acid sequence of fructose 1,6-biphosphate aldolase from eletric organ of Electrophorus electricus (L.). Z Naturforsch C 61: 884-888.
Silva CPS, Santos AL, Gibson DI 2006. A new species of Monocotyle taschenberg, 1878 (Monogenea: Monocotylidae) from Dasyatis guttata (Dasyatidae) . J Parasitol 92: 21-24.
Silva Jr FPS, Ellena J, Lima MF, Mascarenhas YP, N-de-Souza MV, Vasconcelos TRA, Wardell JL 2006. Experimental and Theoretical Structure Characterization of Two Isoniazid Derivatives. J Mol Struct 788: 63-71.
Silva Jr FP, Antunes O, de-Alencastro RB, De-Simone SG 2006. The Na+ binding channel of human coagulation proteases: Novel insights on the structure and allosteric modulation revealed by molecular surface analysis. Biophys Chem 119: 282-294.
Salles JB, Bastos VLC, Silva Filho MV, Machado OL, Salles CM, De-Simone SG, Bastos JC 2006. A novel butyrylcholinesterase from serum of Leporinus macrocephalus, a Neotropical fish. Biochimie 88: 59-68.
Salles CM, Guedes HL, Salles JB, Silva Jr FP, De-Simone SG 2006. Optimization of sample preparation from skin mucus of a neotropical fish for two-dimensional substrate gel electrophoresis. Anal Biochem 357: 153-155.
De-Simone SG, Correa Netto C, Silva Jr FP 2006. Simple affinity chromatographic procedure to purify beta-galactoside binding lectins. J Chromatogr B 838: 135-138.
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