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ARTIGOS CIENTÍFICOS

Confira a lista dos artigos publicados em periódicos indexados pelos pesquisadores do Laboratório de Bioquímica de Trpanossomatídeos do Instituto Oswaldo Cruz (IOC/Fiocruz):

2014

Indexado (fator de impacto >=1 e < 2,71)

Campos COM, Leon LL, Taylor, M.C., Kelly, J.M. 2014. Benzidazole-resistance in Trypanosoma cruzi:Evidence that distinct mechanisms can actb in concert.. Mol Biochem Parasit 193: 17-19.

Faiões VS, Leon LL, Cavalheiro MMC, Santos ECT, Bernardino, A.M.R., Vegi, P., Santos, M. 2014. Effectiveness of novel 5-(5-amino-21-aryl-1H-pyrazol-4-yl)-1H-tetrazole derivatives aggainst promastigotes ad amastigotes of Leishmania amazonenses. Chem Biol Drug Des 83: 272-277.

Giarola NL, Silveira TS, Inácio Filho JD, Viieira LP, Amaral EEA, Meyer-Fernandes JR 2014. Leishmania amazonensis: Increase in ecto-ATPase activity and parasite burden of vinblastine-resistant protozoa.. Exp Parasitol 146: 25-33.

Ferreira-de-Vasconcelos M, Cunha Jr EF, Andrade-Neto VV, Larissa Moreira Siqueira, d Avila-Levy CM, Marcele Moreth, Wilson Cunico, Marcus Vinícius Nora de Souza, Claudia Regina Brandão Gomes, Torres-Santos EC 2014. Oral effectiveness of PMIC4, a novel hydroxyethylpiperazine analogue, in Leishmania amazonensis. Int J Parasitol Drug 4: 210-213.

Indexado (fator de impacto >=2,71 e < 4,35)

Luciana Costa, Roberta O. Pinheiro, Patricia M. L. Dutra, Rosiane F. Santos, Cunha Jr EF, Santos ECT, Alcides J. M. da Silva, Paulo R.R. Costa, Silvia A. G. da-Silva 2014. Pterocarpanquinone LQB-118 Induces Apoptosis in Leishmania (Viannia) braziliensis and Controls Lesions in Infected Hamsters.. PLoS One 9: - .

Indexado (fator de impacto >=4,35 e < 7,51)

Inácio Filho JD, Oliveira LGF, Cavalheiro MMC, Amaral EEA 2014. The Effect of (-)-Epigallocatechin 3-O - Gallate In Vitro and In Vivo in Leishmania braziliensis: Involvement of Reactive Oxygen Species as a Mechanism of Action.. PLoS Neglect Trop D 8: - .


Faiões VS, Dos Santos MS, Bernardino AM, Cunha Jr EF, Cavalheiro MMC, Santos ECT 2014. The New Pyrazolyltetrazole Derivative MSN20 Is Effective via Oral Delivery against Cutaneous Leishmaniasis. Antimicrob Agents Ch 58(10): 6290-6293.

2013

Indexado (fator de impacto < 1 ou sem FI)
Vanessa da Silva Carrara, Cunha Jr EF, Santos ECT, Arlene Gonçalves Corrêa, Julia L. Monteiro, Izabel Galhardo Demarchi, Maria Valdrinez Campana Lonardoni, Diógenes Aparício Garcia Cortez 2013. Antileishmanial activity of amides from Piper amalago and synthetic analogs. Rev Bras Farmacogn 23: 1-8.

Indexado (fator de impacto >=1 e < 2,71)
Soares-Bezerra, RJ, Leon LL, Echevarria A, Reis CM, Gomes-Silva L, Agostinho CG, Fernandes RA, Cavalheiro MMC, Genestra MS 2013. In vitro evaluation of 4-phenyl-5-(4-X-phenyl)-1,3,4-thiadiazolium-2-phenylaminide chlorides and 3[N-4-X-phenyl]-1,2,3-oxadiazolium-5-olate derivatives on nitric oxide synthase and arginase activities of Leishmania amazonensis. Exp Parasitol 135: 50-54.

Campos COM, Castro-Pinto DB, Ribeiro GA, Berredo-Pinho MM, Gomes LH, da Silva Bellieny MS, Goulart CM, Echevarria A, Leon LL 2013. P-glycoprotein efflux pump plays an important role in Trypanosoma cruzi drug resistance. Parasitol Res 112: 2341-2351.

Faria JV, Dos Santos MS, Bernardino AM, Becker KM, Machado GMC, Rodrigues RF, Cavalheiro MMC, Leon LL 2013. Synthesis and activity of novel tetrazole compounds and their pyrazoe-4-carbonitrile precursors against Leishmania spp.. Bioorg Med Chem Lett 23: 6310-6312.

Charret KS, Lagrota-Candido J, Carvalho-Pinto CE, Hottz CF, Lira ML, Rodrigues RF, Gomes AO, Bernardino AM, Cavalheiro MMC, Leon LL, Amaral VF 2013. The histopathological and immunological pattern of CBA mice infected with Leishamnia amazonensis after treatment with pyrazole carbohydozide derivates.. Exp Parasitol 133: 201-210.

Giarola NL, de Almeida-Amaral EE, Collopy-Júnior I, Fonseca-de-Souza AL, Majerowicz D, Paes LS, Gondim KC, Meyer-Fernandes JR 2013. Trypanosoma cruzi: Effects of heat shock on ecto-ATPase activity. Exp Parasitol 133: 434-441.

Indexado (fator de impacto >=2,71 e < 4,35)
Inácio Filho JD, Cavalheiro MMC, Amaral EEA 2013. In Vitro and in Vivo Effects of (-)-Epigallocatechin 3-O-gallate on Leishmania amazonensis. J Nat Prod 76: 1993-1996.

Silva FFE, Inácio Filho JD, Cavalheiro MMC, Amaral EEA 2013. Reactive Oxiygen Species Production by Quercetin Causes the Death of Leishmania amazonensis Intracellular Amastigotes.. J Nat Prod 76: 1505-1508.

Claudio Eduardo Rodrigues-Santos, Leon LL, Adailton J. Bortoluzzi, Cavalheiro MMC, Machado GMC, Aurea Echevarria 2013. Synthesis, antileishmanial activity and structure-activity relationship of 1-N-X-phenyl-3-N-Y-phenyl-benzamidines. Eur J Med Chem 67: 166-174.

Indexado (fator de impacto >=4,35 e < 7,51)
Ribeiro GA, Cunha-Junior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC 2013. LBQ-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. J Antimicrob Chemoth 68: 789-799.

2012

Indexado (fator de impacto < 1 ou sem FI)
Leite AC, Kato MJ, Soares RO, Guimarães AE, Santos-Mallet JR, Cabral MM 2012. Grandisin caused morphological changes larval and toxicity on Aedes aegypti. Rev Bras Farmacogn 22: 517-521.

Indexado (fator de impacto >=1 e < 2,71)
Marra RK, Bernardino AM, Proux TA, Charret KS, Lira ML, Castro HC, Souza AM, Oliveira CD, Borges JC, Rodrigues CR, Canto-Cavalheiro MM, Leon LL, Amaral VF 2012. 4-(1H-Pyrazol-1-yl) benzenesulfonamide derivatives: identifying new active antileishmanial structures for use against a neglected disease. Molecules 17: 12962-12973  GRÁTIS 12962-12973 .

Moura do Carmo DF, Amaral AC, Machado GM, Leon LL, de Andrade Silva JR 2012. Chemical and biological analyses of the essential oils and main constituents of Piper species. Molecules 17: 1819-1829.

Carrara VS, Serra LZ, Cardozo-Filho L, Cunha-Júnior EF, Torres-Santos EC, Cortez DA 2012. HPLC analysis of supercritical carbon dioxide and compressed propane extracts from Piper amalago L. with antileishmanial activity. Molecules 17: 15-33.

Lacerda DI, Cysne-Finkelstein L, Nunes MP, De-Luca PM, Genestra MS, Leon LL, Berredo-Pinho M, Mendonça-Lima L, Matos DC, Medeiros MA, Mendonça SC 2012. Kinetoplastid membrane protein-11 exacerbates infection with Leishmania amazonensis in murine macrophages. Mem Inst Oswaldo Cruz 107: 238-245.

De Cicco NN, Pereira MG, Corrêa JR, Andrade-Neto VV, Saraiva FB, Chagas-Lima AC, Gondim KC, Torres-Santos EC, Folly E, Saraiva EM, Cunha-e-Silva NL, Soares MJ, Atella GC 2012. LDL uptake by Leishmania amazonensis: Involvement of membrane lipid microdomains. Exp Parasitol 130: 330-340.

Inacio JD, Canto-Cavalheiro MM, Menna-Barreto RF, Almeida-Amaral EE 2012. Mitochondrial damage contribute to epigallocatechin-3-gallate induced death in Leishmania amazonensis. Exp Parasitol 132: 151-155.

Andrade-Neto VV, de Matos-Guedes HL, Gomes DC, Canto-Cavalheiro MM, Rossi-Bergmann B, Torres-Santos EC 2012. The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis. Mem Inst Oswaldo Cruz 107: 416-419.

Indexado (fator de impacto >=2,71 e < 4,35)
Cunha AC, Chierrito TP, Machado GM, Leon LL, da Silva CC, Tanaka JC, de Souza LM, Gonçalves RA, de Oliveira AJ 2012. Anti-leishmanial activity of alkaloidal extracts obtained from different organs of Aspidosperma ramiflorum. Phytomedicine 19: 413-417.

Rodrigues RF, Castro-Pinto D, Echevarria A, dos Reis CM, Del Cistia CN, Sant’Anna CM, Teixeira F, Castro H, Canto-Cavalheiro M, Leon LL, Tomás A 2012. Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies. Bioorgan Med Chem 20: 1760-1766.

Indexado (fator de impacto >=4,35 e < 7,51)
Rodrigues RF, Charret KS, Campos MC, Amaral V, Echevarria A, dos Reis C, Canto-Cavalheiro MM, Leon LL 2012. The in vivo activity of 1,3,4-thiadiazolium-2-aminide compounds in the treatment of cutaneous and visceral leishmaniasis. J Antimicrob Chemother 67: 182-190.

Schmidt TJ, Khalid SA , Romanha A.J, Alves TM, Biavatti MW , Brun R, da Costa FB, de Castro SL, Ferreira VF , de Lacerda MV, Lago JH , Leon LL, Lopes NP , das Neves Amorim RC , Niehues M, Ogungbe IV, Pohlit AM , Scotti MT , Setzer WN , de N C Soeiro M, Steindel M, Tempone AG 2012. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part I. Curr Med Chem 19: 2128-2175.

Schmidt TJ, Khalid SA , Romanha AJ , Alves TM, Biavatti MW, Brun R, Da Costa FB, de Castro SL, Ferreira VF, de Lacerda MV, Lago JH, Leon LL, Lopes NP, das Neves Amorim RC, Niehues M, Ogungbe IV, Pohlit AM, Scotti MT, Setzer WN, de N C Soeiro M, Steindel M, Tempone AJ 2012. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part II. Curr Med Chem 19: 2176-2228.

2011

da Cunha-Júnior EF, Pacienza-Lima W, Ribeiro GA, Netto CD, do Canto-Cavalheiro MM, da Silva AJ, Costa PR, Rossi-Bergmann B, Torres-Santos EC. Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis. Antimicrob. Chemother. (2011) 66 (7): 1555-1559.

Fonseca-Silva F, Inacio JD, Canto-Cavalheiro MM, Almeida-Amaral EE.  Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis. PLoS One. 2011 Feb 8;6(2):e14666.

2010

Campos MC, Salomão K, Castro-Pinto DB, Leon LL, Barbosa HS, Maciel MA, de Castro SL 2010. Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi. Parasitol Res 107: 1193-1204.

Da-Cruz AM, Matta NE, Cysne-Finkelstein L, Machado GM, Leon L 2010. Differences in the antigenic profile and infectivity of murine macrophages of Leishmania (Viannia) parasites. J Parasitol 96: 509-515.

Almeida-Amaral EE, Cardoso VC, Francioli FG, Meyer-Fernandes JR 2010. Leishmania amazonensis: heme stimulates (Na(+)+K(+))ATPase activity via phosphatidylinositol-specific phospholipase C/protein kinase C-like (PI-PLC/PKC) signaling pathways. Exp Parasitol 124: 436-441.

Cabral MM, Barbosa-Filho JM, Maia GL, Chaves MC, Braga MV, de Souza W, Soares RO 2010. Neolignans from plants in northeastern Brazil (Lauraceae) with activity against Trypanosoma cruzi. Exp Parasitol 124: 319-324.

2009

Costa EV; Pinheiro MLB, Silva JRA, Maia BHLNS, Duarte MCT, Amaral ACF, Machado GMC, Leon LL; Antimicrobial and antileishmanial activity of essential oil from the leaves of Annona foetida (Annonaceae), 2009, Química Nova, volume 32, Issue 1, pages 78-81.

Silva AJM, Chaquip D. Netto CD, Pacienza-Lima W, Torres-Santos EC, Rossi-Bergmann B, Maurel S, Alexis Valentin A, Costa PRR; Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives, 2009, Journal of the Brazilian Chemical Society, volume 20, Issue 1, pages 176-182.

Silva JRA, Carmo DFM, Reis EM, Machado GMC, Leon LL, Silva BO, Ferreira JLP, Amaral ACF; Chemical and biological evaluation of essential oils with economic value from Lauraceae species, 2009, Journal of the Brazilian Chemical Society, volume 20, Issue 6, pages 1071-1076.

Charret KS, Rodrigues RF, Bernardino AMR, Gomes AO, Carvalho AV, Canto-Cavalheiro MM, Leon L, Amaral VF, Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis, 2009, American Journal of Tropical Medicine and Hygiene, volume 80, Issue 4, pages 568-73.

Matta NE, Nogueira RS, Franco AMR, Souza IS, Mattos MS, Oliveira-Neto MP, Coutinho SG, Leon LL, Da-Cruz AM, Leishmania (Viannia) guyanensis induces low immunological responsiveness in leishmaniasis patients from endemic area of the Brazilian Amazon highland, 2009, American Journal of Tropical Medicine and Hygiene, volume 80, Issue 3, pages 339-344.

Chaves SP, Torres-Santos EC, Marques C, Figliuolo VR, Persechini PM, Coutinho-Silva R, Bergmann BR, Modulation of P2X7 purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination, 2009, Microbes and Infection, volume 11, Issue 10-11, pages 842-849.

Fabrino DL, Bleck CKE, Arles E, Hasilik A, Melo RCN, Niederweis M, Griffiths G, Gutierrez MG, Porins facilitate nitric oxide-mediated killing of mycobacteria, 2009, Microbes and Infection, volume 11, Issue 10-11, pages 868-75. 

Santos ECT, Sampaio-Santos MI, Buckner FS, Yokoyama K, Gelb M, Urbina JA, Bergmann BR; Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone, 2009, Jornal of Antimicrobial Chemotherapy, volume 63, Issue 3, pages 469-472.

Rodrigues RF, Charret KS, silva EF, Echevarria A, Amaral VF, Leon LL, Cavalheiro MMC; Antileishmanial Activity of 1,3,4-Thiadiazolium-2-Aminide in Mice Infected with Leishmania amazonensis, 2009, Antimicrobial Agents Chemotherapy, volume 53, Issue 2, pages 839-842.

2008

Castro-Pinto DB, Genestra MS, Leon LL, Waghabi MC, Menezes GTB, Gonçalves AJS, Cistia CND, SANTANNA, C. M. R, Mendonça-Lima L 2008. Cloning and expression of trypanothione reductase from a New World Leishmania species. Arch Microbiol 189: 375-384.

Soares-Bezerra RJ, da Silva EF, Echevarria Á, Silva LG, Cysne-Finkelstein L, Monteiro FP, Leon LL, Genestra M 2008. Effect of mesoionic 4-phenyl-5-(cinnamoyl)-1,3,4-thiadiazolium-2-phenylamine chloride derivative salts on the activities of the nitric oxide synthase and arginase of Leishmania amazonensis. J Enzym Inhib Med Ch 23: 328-333.

Genestra M, Soares-Bezerra RJ, Gomes-Silva L, Fabrino DL, Bellato-Santos T, Castro-Pinto DB, Canto-Cavalheiro MM, Leon LL 2008. In vitro sodium nitroprusside-mediated toxicity towards Leishmania amazonensis promastigotes and axenic amastigotes. Cell Biochem Funct 26: 709-717.

2007

Rodrigues RF, da Silva EF, Echevarria A, Bonin RF, Amaral VF, Leon LL, Cavalheiro MMC 2007. A comparative study of mesoionic compounds in Leishmania sp. and toxicity evaluation. Eur J Med Chem 42: 1039-1043.

Machado GMC, Leon LL, Castro SL 2007. Activity of Brazilian and Bulgarian propolis against different species of Leishmania. Mem Inst Oswaldo Cruz 102: 73-77.

Tanaka JC, da SIlva CC, Ferreira IC, Machado GMC, Leon LL, de Oliveira AJ 2007. Antileishmanial activity of indole alkaloids from Aspidosperma ramiflorum. Phytomedicine 14: 377-380.

Castro-Pinto DB, Lima ELS, Cunha AS, Genestra MS, Léo RMM, Monteiro F, Leon LL 2007. Leishmania amazonensis trypanothione reductase: evaluation of the effect of glutathione analogs on parasite growth, infectivity and enzyme activity. J Enzyme Inhib Med Chem 22: 71-75.

Genestra MS 2007. Oxyl radicals, redox-sensitive signaling cascades and antioxidants. Cell Signal 19: 1807-1819.

Ferreira SB, Costa MS, Boechat N. , Soares-Bezerra RJ, Genestra MS, Canto-Cavalheiro MM, Kover WB, Ferreira VF 2007. Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents. Eur J Med Chem 42: 1388-1395.

2006

Pinero J, Temporal RM, Silva-Gonçalves AJ, Jimenez IA, Bazzocchi IL, Oliva A, Perera A, Leon LL, Valladares B 2006. New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis. Acta Trop 98: 59-65.

Genestra MS, Guedes-Silva D, Souza WJ, Cysne-Finkelstein L, Soares-Bezerra RJ, Monteiro FP, Leon LL 2006. Nitric oxide synthase (NOS) characterization in Leishmania amazonensis axenic amastigotes. Arch Med Res 37: 328-333.

Costa EV, Pinheiro ML, Xavier CM, Silva JR, Amaral AC, Souza AD, Barison A, Campos FR, Ferreira AG, Machado GM, Leon LL 2006. A pyrimidine-beta-carboline and other alkaloids from Annona foetida with antileishmanial activity.. J Nat Prod 69: 292-294.

Genestra M, Souza WJ, Guedes-Silva D, Machado GM, Cysne-Finkelstein L, Bezerra RJ, Monteiro F, Leon LL 2006. Nitric oxide biosynthesis by Leishmania amazonensis promastigotes containing a high percentage of metacyclic forms. Arch Microbiol 185: 348-354.

Bernardino AM, Gomes AO, Charret KS, Freitas AC, Machado GM, Canto-Cavalheiro MM, Leon LL, Amaral VF 2006. Synthesis and leishmanicidal activities of 1-(4-X-phenyl)-N-[(4-Y-phenyl) methylene]-1H-pyrazole-4-carbohydrazides.. Eur J Med Chem 41: 80-87.