Instituto Oswaldo Cruz - Ciência para a Saúde da População Brasileira

ARTIGOS CIENTÍFICOS

Confira a lista dos artigos científicos publicados em periódicos indexados desde 2006 pelos pesquisadores do Laboratório de Biologia Celular do Instituto Oswaldo Cruz (IOC/Fiocruz):

2014

Indexado (fator de impacto < 1 ou sem FI)

W A Marques , Gomes SAO, D B Almeida , J P F Pacheco, Menna-Barreto RFS, Santos-Mallet JR, C L Cesar, D Feder 2014. Evidence of autophagy in trypanosoma cruzi cells by quantum dots. Acta Microsc 23: 1-10.

Indexado (fator de impacto >=1 e < 2,71)

Silva Júnior EN, Jardim GAM, Menna-Barreto RFS, Castro SL 2014. Anti-Trypanosoma cruzi compounds: Our contribution for the evaluation and insights on the mode of action of naphthoquinones and derivatives. J Brazil Chem Soc 0: 1-19.

Araújo AF, Oliveira GM, Vasconcelos JF, Ersching J, Vasconcelos JR, Machado AV, Soares MB, Soares MB 2014. Genetic vaccination against experimental infection with myotropic parasite strains of Trypanosoma cruzi. Mediat Inflamm 2014: - .

Timm, B, Marcos Meuser Batista, Jessica, Hammer, ER, Brun, R, Soeiro MNC 2014. In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi.. Parasitology 141: 367-373.

Timm,B, Silva PB, Marcos Meuser Batista, Farahat AA, Kumar A, Boykin DW, Soeiro MNC 2014. In vitro investigation of the efficacy of novel diamidines against Trypanosoma cruzi.. Parasitology 15: 1272-1276.

Carvalho AS, Salomão K, Castro SL, Conde TR, Zamith HPS, Caffarena ER, Hall BS, Wilkinson SR, Boechat N 2014. Megazol and its bioisostere 4H-1,2,4-triazole: Comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the T. brucei nitroreductase enzyme (tbNTR). Mem I Oswaldo Cruz 109: 315-323.

Peixoto MC, Souza CF, Menna-Barreto RFS, Nogueira NPA, Laranja GAT, Sabino KC, Coelho MGP , Oliveira MM, Paes MC 2014. Trypanosomatid essential metabolic pathway: New approaches about heme fate in Trypanosoma cruzi. Biochem Bioph Res Co 449: 216-221.

Indexado (fator de impacto >=2,71 e < 4,35)

Sangenito LS, Menna-Barreto RFS, d Avila-Levy CM, Santos ALS, Branquinha MH 2014. Decoding the anti-Trypanosoma cruzi action of HIV peptidase inhibitors using epimastigotes as a model. PLoS One 2: - .

Gomes NLS, Vidal VE, Marcos Meuser Batista, Soeiro MNC, Menna-Barreto RFS, da Cruz Moreira O 2014. Nucleoside triphosphate diphosphohydrolase1 (TcNTPDase-1) gene expression is increased due to heat shock and in infective forms of Trypanosoma cruzi. Parasite Vector 7(1): - .

Brunro G, Caminha MA, Ferreira AT, Leprevost F, Carvalho PC, Perales J, Valente RH, Menna-Barreto RFS 2014. Reevaluating the Trypanosoma cruzi proteomic map: The shotgun description of bloodstream trypomastigotes. J Proteomics 115C: 58-65.

Menna-Barreto RFS, Castro SL 2014. The double-edged sword in pathogenic trypanosomatids: the pivotal role of mitochondria in oxidative stress and bioenergetics. BioMed Res Int ID 614014: - .

Indexado (fator de impacto >=4,35 e < 7,51)

Nair DK, Menna-Barreto RFS, Silva Júnior EN, Mobin SM, Namboothiri IN 2014. Chiral squaramide-catalyzed asymmetric synthesis of pyranones and pyranonaphthoquinones via cascade reactions of 1,3-dicarbonyls with Morita-Baylis-Hillman acetates of nitroalkenes. Chem Comm 50: 6973-6976.

Siciliano-de-Araújo J, Silva PB, Marcos Meuser Batista, Silva CF, Patrick DA, Kilgore Jones S, Bakunov SA, Bakunova SM, Soeiro MNC 2014. In vitro and In vivo Biological Effect of Novel Arylimidamide Derivatives Against Trypanosoma cruzi. Antimicrob Agents Ch 58(7): 3720-3726.

Guimarães DA, Silva MRS, Lana M 2014. Sesquiterpene lactone in nanostructured parenteral dosage form is efficacious in experimental Chagas disease. Antimicrob Agents Ch 58: 2067-2075.

Silva CF, Batista, DGJ, Silva PB, Meuser MB, Claudia Aiub, da Silva, MF, Araújo-Lima, CF, Banerjee M, , Farahat AA, Stephens CE, Kumar A,, Boykin, D, Soeiro MNC 2014. The biological activity of novel arylimidamides against Trypanosoma cruzi: in vitro and in vivo studies.. Antimicrob Agents Ch 58(7): 4191-4195.

Qualis B1
Rocha DR, Souza AMT, Souza ACG, Castro HC, Rodrigues C, Menna-Barreto RFS, Castro SL, Ferreira V 2014. Effect of 9-hydroxy-á- and 7-hydroxy-â-pyran naphthoquinones on Trypanosoma cruzi and structure-activity relationship studies. Medicinal Chemistry 10(6): 564-570.

2013

Indexado (fator de impacto >=1 e < 2,71)
Borges da Silva R, Loback VB, Salomão K, de Castro SL, Wardell JL, Wardell SM, Costa TE, Penido C, Henriques MG, Carvalho SA, da ilva EF, Fraga CA 2013. Article synthesis and trypanocidal activity of novel 2,4,5-triaryl-N-hydroxylimidazole derivatives. Molecules 18: 3445-3457.

Demarque KC, Cascabulho CM, Batista WS, Oliveira FS, Oliveira GM 2013. Increased TNF serum levels are related to highly aggressive behavior in male Swiss Webster mice. Lab Anim-UK 100: 100-101.

Rochael NC, Lima LG, Oliveira SM, Barcinski MA, Saraiva E, Monteiro RQ, Pinto-da-Silva LH 2013. Leishmania amazonensis exhibits phosphatidylserine-dependent procoagulant activity, a process that is counteracted by sandfly saliva. Mem I Oswaldo Cruz 108: 679-685.

Soeiro MNC, Werbovetz K, Boykin DW, Wilson WD, Wang MZ, Hemphill A 2013. Novel amidines and analogues as promising agents against intracellular parasites: a systematic review.. Parasitology 140: 929-951.

Wanderley JL, Thorpe PE, Barcinski MA, Soong L 2013. Phosphatidylserine exposure on the surface of Leishmania amazonensis amastigotes modulates in vivo infection and dendritic cell function. Parasite Immunol 35: 109-119.

Indexado (fator de impacto >=2,71 e < 4,35)

Nogueira NPA , MORGADO-DÍAZ JA , Menna-Barreto RFS, Paes MC, Silva-López RE 2013. Effects of a marine serine protease inhibitor on viability and morphology of Trypanosoma cruzi, the agent of Chagas disease. Acta Trop 128: 27-35.

Rebello KM, Menna-Barreto RFS, Moutinho V, Mota EM, Perales J, Ferreira AGCN, Oliveira-Menezes, A, Lenzi H 2013. Morphological aspects of Angiostrongylus costaricensis by light and scanning electron microscopy. Acta Trop 127: 191-198.

Gouvea LR, Martins DA, Batista, DGJ, Soeiro MNC, Louro SR, Barbeira PJ, Teixeira LR 2013. Norfloxacin Zn(II)-based complexes: acid base ionization constant determination, DNA and albumin binding properties and the biological effect against Trypanosoma cruzi.. Biometals 26: 813-825.

Diogo EBT, Dias GG, Rodrigues BL, Guimarães TT, Valença WO, Camara CA, Oliveira RN, Silva MG, Ferreira VF, Paiva YG, Goulart MOF, Menna-Barreto RFS, Castro SL, Silva Junior EN 2013. Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: Electrochemical studies on the effects of the quinoidal moiety. Bioorgan Med Chem 21: 6337-6348.

Castro SL, Emery FS, Silva Junior EN 2013. Synthesis of Quinoidal Molecules: Strategies towards Bioactive Compounds with an Emphasis on Lapachones. Eur J Med Chem 69: 678-700.

Salomão K, Santana NA, Molina MT, Castro SL, Menna-Barreto RFS 2013. Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues. BMC Microbiol 13: - .

Indexado (fator de impacto >=4,35 e < 7,51)

Silva CF, Batista, DGJ, Siciliano-de-Araújo J, Marcos Meuser Batista, Jessica Lionel, Souza EM, Erica Ripoll Hammer, Silva PB, De Mieri M, Adams M, Zimmermann S, Hamburger M B, Brun R, Schühly W, Soeiro MNC 2013. Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo. Antimicrob Agents Ch 57: 5307-5314.

Soeiro MNC, Souza EM, Silva CF, Batista, DGJ, Marcos Meuser Batista, Pavão BP, Siciliano-de-Araújo J, Aiub C, Silva PB, Lionel JR, Britto CFPC, Kim K, Sulikowski G, Hargrove TY, Waterman MR, Lepesheva GL 2013. In vitro and in vivo studies of the antiparasitic activity of sterol 14á-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.. Antimicrob Agents Ch 57: 4151-4163.

2012

Indexado (fator de impacto < 1 ou sem FI)
EL-Hani CN, Borges VM , Wanderley JL, Barcinski MA 2012. Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective. Front Cell Infect Microbiol 2: - .

Mendes Wanderley JL, Costa JF, Borges VM, Barcinski M 2012. Subversion of immunity by Leishmania amazonensis parasites: possible role of phosphatidylserine as a main regulator. J Parasitol Res 2012: - .

Indexado (fator de impacto >=1 e < 2,71)
da Silva DR, de Castro SL, Alves MC, Batista WS, de Oliveira GM 2012. Acute experimental Trypanosoma cruzi infection: Establishing a murine model that utilises non-invasive measurements of disease parameters. Mem Inst Oswaldo Cruz 107: 211-216.

Inácio JD, Canto-Cavalheiro MM, Menna-Barreto RF, Almeida-Amaral EE 2012. Mitochondrial damage contribute to epigallocatechin-3-gallate induced death in Leishmania amazonensis. Exp Parasitol 132: 151-155.

Arriaza B, Orellana NC, Barbosa HS, Menna-Barreto RF, Araújo A, Standen V 2012. Severe head lice infestation in an Andean mummy of Arica, Chile. J Parasitol 98: 433-436.

Albuquerque DD, Brener B, Menna-Barreto RF, Bruno SF 2012. The first identification of Nymphicilichus perezae Mironov and Galloway, 2002 in cockatiels in Brazil and the first record of Psittophagus sp. Gaud and Atyeo, 1996 and cf. Dubininia sp. Vassilev, 1958 in cockatiels (Nymphicus hollandicus Kerr, 1792). Parasitol Int 61: 572-578.

Indexado (fator de impacto >=2,71 e < 4,35)
Fernandes MC, da Silva EN, PInto AV, de Castro SL, Menna-Barreto RF 2012. A novel triazolic naphthofuranquinone induces autophagy in reservosomes and impairment of mitosis in Trypanosoma cruzi. Parasitology 139: 26-36.

Martins DA, Gouvea LR, da Gama Jean Batista D, da Silva PB, Louro SR, de Nazare C Soeiro M, Teixeira LR 2012. Copper(II)-fluoroquinolone complexes with anti-Trypanosoma cruzi activity and DNA binding ability. Biometals 25: 951-960.

Carvalho SA, Feitosa LO, Soares M, Costa TE, Henriques MG, Salomão K, de Castro SL, Kaiser M, Brun R, Wardell JL, Wardell SM, Trossini GH, Andricopulo AD, da Silva EF, Fraga CA 2012. Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. Eur J Med Chem 54: 512-521.

França-Costa J , Wanderley JL, Deolindo P, Zarattini JB, Costa J, Soong L, Barcinski MA, Barral A, Borges VM 2012. Exposure of phosphatidylserine on Leishmania amazonensis isolates is associated with diffuse cutaneous leishmaniasis and parasite infectivity. PLoS One 7: -

da Silva CF, Batista DG, Oliveira GM, de Souza EM, Hamer ER, da Silva PB, Daliry A, Araújo JS, Britto C, Rodigues AC, Liu Z, Farahat AA, Kumar A, Boykin DW, Soeiro MN 2012. In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form - DB1965 - against Trypanosoma cruzi infection. PLoS One 7: - .

da Silva EN Jr, de Melo IM, Diogo EB, Costa VA, Verenice A, de Souza Filho JD, Valença WO, Camara CA, de Oliveira RN, de Araujo AS, Emery FS, dos Santos MR, de Simone CA, Menna-Barreto RF, de Castro SL 2012. On the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions. Eur J Med Chem 52: 304-312.

Indexado (fator de impacto >=4,35 e < 7,51)
Zhu X, Liu Q, Yang S, Parman T, Green CE, Mirsalis JC, de Nazaré Correia Soeiro M, Mello de Souza E, da Silva CF, da Gama Jaen Batista D, Stephens CE, Banerjee M, Farahat AA, Munde M, Wilson WD, Boykin DW, Wang MZ, Werbovetz KA 2012. Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas´ disease - In vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies. Antimicrob Agents Chemother 56: 3690-3699.

Klionsky DJ, Menna-Barreto RF, and 1023 others 2012. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544.

de Oliveira FL, Araujo-Jorge TC, de Souza EM, de Oliveira GM, Degrave WM, Feige JJ, Bailly S, Waghabi MC 2012. Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease. PLoS Negl Trop Dis 6: -

Schmidt TJ, Khalid SA, Romanha AJ, Alves TM, Biavatti MW, Brun R, Da Costa FB, de Castro SL, Ferreira VF, de Lacerda MV, Lago JH, Leon LL, Lopes NP, das Neves Amorim RC, Niehues M, Ogungbe IV, Pohlit AM, Scotti MT, Setzer WN, Soeiro MN, Steindel M, Tempone AG 2012. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part I. Curr Med Chem 19: 2128-2175.

2011

Da Silva CF, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Som P, Boykin DW, Soeiro Mde N. In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi. J Antimicrob Chemother. 2011 Jun;66(6):1295-7. J Antimicrob Chemother http://jac.oxfordjournals.org/content/66/6/1295.full.pdf+html

De Souza EM, da Silva PB, Nefertiti AS, Ismail MA, Arafa RK, Tao B, Nixon-Smith CK, Boykin DW, Soeiro MN. Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi. Exp Parasitol. 2011 Feb;127(2):429-35.

Duszenko M, Ginger ML, Brennand A, Gualdrón-López M, Colombo MI, Coombs GH, Coppens I, Jayabalasingham B, Langsley G, de Castro SL, Menna-Barreto R, Mottram JC, Navarro M, Rigden DJ, Romano PS, Stoka V, Turk B, Michels PA. Autophagy in protists. Autophagy. 2011 Feb;7(2):127-58. Epub 2011 Feb 1.

Ennes-Vidal V, Menna-Barreto RFS, Santos ALS, Branquinha MH, Dávila –Levy CM, MDL28170, a Calpain Inhibitor, Affects Trypanosoma cruzi Metacyclogenesis, Ultrastructure and Attachment to Rhodnius prolixus Midgut, 2011, Plos One, Apr 4;6(4):e18371

Ferreira SB, Salomão K, de Carvalho da Silva F, Pinto AV, Kaiser CR, Pinto AC, Ferreira VF, de Castro SL. Synthesis and anti-Trypanosoma cruzi activity of β-lapachone analogues. Eur J Med Chem. 2011 Jul;46(7):3071-7. Epub 2011 Mar 15.

Hausen MA, Menna-Barreto RF, Lira DC, de Carvalho L, Barbosa HS. Synergic effect of metronidazole and pyrantel pamoate on Giardia lamblia. Parasitol Int. 2011 Jan;60(1):54-8. Epub 2010 Oct 12.

Lannes-Vieira J, Pereira IR, Vinagre NF, Arnez LE. TNF-alpha and TNFR in Chagas disease: From protective immunity to pathogenesis of chronic cardiomyopathy. Adv Exp Med Biol. 2011;691:221-30.

Oliveira JH, Gonçalves RL, Lara FA, Dias FA, Gandara AC, Menna-Barreto RF, Edwards MC, Laurindo FR, Silva-Neto MA, Sorgine MH, Oliveira PL. Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota. PLoS Pathog. Mar;7(3):e1001320. Epub 2011 Mar 17.

Soeiro M de N, de Castro SL. Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies. Open Med Chem J. 2011 Mar; 5: 21–30.

Vieira CS, Almeida DB, Thomaz AA, Menna-Barreto RF, Santos-Mallet JR, Cesar CL, Gomes SA, Feder D. Studying nanotoxic effects of CdTe quantum dots in Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz. Mar;106(2):158-65.

2010

Kikuchi SA, Sodré CL, Kalume DE, Elias CG, Santos AL, de Nazaré Soeiro M, Meuser M, Chapeaurouge A, Perales J, Fernandes O 2010. Proteomic analysis of two Trypanosoma cruzi Zymodeme 3 strains. Exp Parasitol 126: 540-551.

Olivieri BP, Molina JT, Castro SL, Pereira MC, Urbina JA, Araújo-Jorge TC 2010. A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease. Int J Antimicrob Agents 36: 79-83.

Menna-Barreto RF, Beghini DG, Ferreira AT, Pinto AV, de Castro SL, Perales J 2010. A proteomic analysis of the mechanism of action of naphthoimidazoles in Trypanosoma cruzi epimastigotes in vitro. J Proteomics 73: 2306-2315.

Batista DG, Pacheco MG, Kumar A, Branowska D, Ismail MA, Hu L, Boykin DW, Soeiro MN 2010. Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi. Parasitology 137: 251-259.

Salomão K, de Souza EM, Henriques-Pons A, Barbosa HS, de Castro SL 2010. Brazilian green propolis: Effects in vitro and in vivo on Trypanosoma cruzi. Evid Based Complement Alternat Med.

de Souza EM, Nefertiti AS, Bailly C, Lansiaux A, Soeiro MN 2010. Differential apoptosis-like cell death in amastigote and trypomastigote forms from Trypanosoma cruzi-infected heart cells in vitro. Cell Tissue Res 341: 173-180.

Romanha AJ, de Castro SL, Soeiro MN, Lannes-Vieira J, Ribeiro I, Talvani A, Bourdin B, Blum B, Olivieri B, Zani C, Spadafora C, Chiari E, Chatelain E, Chaves G, Calzada JE, Bustamante JM, Freitas-Junior LH, Romero LI, Bahia MT, Lotrowska M, Soares M, Andrade SG, Armstrong T, Degrave W, Andrade ZA 2010. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem Inst Oswaldo Cruz 105: 233-238.

De Souza AP, Jelicks LA, Tanowitz HB, Olivieri BP, Medeiros MM, Oliveira GM, Pires AR, dos Santos AM, Araújo-Jorge TC 2010. The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice. Mem Inst Oswaldo Cruz 105: 746-751.

Da Silva CF, da Silva PB, Batista MM, Daliry A, Tidwell RR, Soeiro MN 2010. The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi. Mem Inst Oswaldo Cruz 105: 239-245.

Da Silva EN Jr, Guimarães TT, Menna-Barreto RF, Pinto MC, de Simone CA, Pessoa C, Cavalcanti BC, Sabino JR, Andrade CK, Goulart MO, de Castro SL, Pinto AV 2010. The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-lapachone-based 1,2,3-triazoles. Bioorgan Med Chem 18: 3224-3230.

Batista DG, Batista MM, de Oliveira GM, Lannes-Vieira J, Britto CC, Junqueira A, Lima MM, Romanha AJ, Sales Jr PA, Stephens CE, Boykin DW, Soeiro MN 2010. Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas disease treatment. Antimicrob Agents Chemother 54: 2940-2952.

Ennes-Vidal V, Menna-Barreto RF, Santos AL, Branquinha MH, d´Avila-Levy CM 2010. Effects of the calpain inhibitor MDL28170 on the clinically relevant forms of Trypanosoma cruzi in vitro. J Antimicrob Chemother 65: 1395-1398.

Salomão K, de Souza EM, Carvalho SA, da Silva EF, Fraga CA, Barbosa HS, de Castro SL 2010. In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi. Antimicrob Agents Chemother 54: 2023-2031.

Lannes-Vieira JL, de Araujo-Jorge TC, Soeiro MN, Gadelha P, Corrêa-Oliveira R 2010. The centennial of the discovery of Chagas disease: Facing the current challenges. PLoS Negl Trop Dis 4

2009

de Oliveira GM, Masuda MO, Rocha NN, Schor N, Hooper CS, de Araújo-Jorge TC, et al. Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection. Memórias do Instituto Oswaldo Cruz. 2009 Dec;104(8):1063-71.

De Oliveira GM, da Silva TM, Batista WS, Franco M, Schor N. Acute Trypanosoma cruzi experimental infection induced renal ischemic/reperfusion lesion in mice. Parasitology Research. 2009 Dec;106(1):111-20.

Lannes-Vieira J, Soeiro Mde N, Corrêa-
Oliveira R, Araújo-Jorge TC. Chagas disease centennial anniversary celebration: historical overview and prospective proposals aiming to maintain vector control and improve patient prognosis--a permanent challenge. Memórias do Instituto Oswaldo Cruz. 2009 Jul;104 Suppl 1:5-7.

Menna-Barreto RF, Salomão K, Dantas AP, Santa-Rita RM, Soares MJ, Barbosa HS, de Castro SL.. Different cell death pathways induced by drugs in Trypanosoma cruzi: an ultrastructural study. Micron. 2009 Feb;40(2):157-68. Epub 2008 Sep 4. Review.

Soeiro Mde N, Dantas AP, Daliry A, Silva CF, Batista DG, de Souza EM, Oliveira GM, Salomão K, Batista MM, Pacheco MG, Silva PB, Santa-Rita RM, Barreto RF, Boykin DW, Castro SL. Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies. Memórias do Instituto Oswaldo Cruz. 2009 Jul;104 Suppl 1:301-10.

Coutinho L, Ferreira MA, Cosson A, Batista MM, Batista DDJ, Minoprio P, et al.Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection. Memórias do Instituto Oswaldo Cruz. 2009 Dec;104(8):1055-62.

Pinto AV, de Castro SL. The trypanocidal activity of naphthoquinones: a review. Molecules. 2009 Nov 10;14(11):4570-90.

Pacheco M, da Silva CF, de Souza EM, Batista MM, da Silva PB, Kumar A, et al. Trypanosoma cruzi: Activity of heterocyclic cationic molecules in vitro. Experimental Parasitology. 2009 Sep;123(1):73-80.

Batista DG, Pacheco MG, Kumar A, Branowska D, Ismail MA, Hu L, Boykin DW, Soeiro MN. Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi. Parasitology. 2010 Feb;137(2):251-9. Epub 2009 Sep 21.

Correa G, Vilela R, Menna-Barreto RFS, Midlej V, Benchimol M. Cell death induction in Giardia lamblia: Effect of beta-lapachone and starvation. Parasitology International. .2009 Dec;58(4):424-37.

Henriques-Pons A, de Oliveira G. Is the Fas/Fas-L pathway a promising target for treating inflammatory heart disease? J. Cardiovasc. Pharmacol. 2009 Feb;53(2):94-9.

Elingold I, Taboas MI, Casanova MB, Galleano M, Silva RSF, Menna-Barreto RFS, et al. Mechanism of action of novel naphthofuranquinones on rat liver microsomal peroxidation. Chemico-Biological Interactions. 2009 Dec;182(2-3):213-9.

Menna-Barreto RFS, Correa JR, Cascabulho CM, Fernandes MC, Pinto AV, Soares MJ, et al. Naphthoimidazoles promote different death phenotypes in Trypanosoma cruzi. Parasitology. 2009 Apr;136(5):499-510.

Soeiro M, de Castro S. Trypanosoma cruzi targets for new chemotherapeutic approaches. Expert Opin Ther Targets. 2009 Jan;13(1):105-21.

Vannier-Santos M, De Castro S. Electron microscopy in antiparasitic chemotherapy: a (close) view to a kill. Curr Drug Targets. 2009 Mar;10(3):246-60.

Daliry A, Da Silva PB, Da Silva CF, Batista MM, De Castro SL, Tidwell RR, et al. In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi. Journal of Antimicrobial Chemotherapy. 2009 Oct;64(4):747-50. J. Antimicrob. Chemother

de Alencar BC, Persechini PM, Haolla FA, de Oliveira G, Silverio JC, Lannes-Vieira J, Machado AV, Gazzinelli RT, Bruna-Romero O, Rodrigues MM. Perforin and gamma interferon expression are required for CD4+ and CD8+ T-cell-dependent protective immunity against a human parasite, Trypanosoma cruzi, elicited by heterologous plasmid DNA prime-recombinant adenovirus 5 boost vaccination. Infect Immun. 2009 Oct;77(10):4383-95. Epub 2009 Aug 3.

Waghabi MC, de Souza EM, de Oliveira GM, Keramidas M, Feige JJ, Araujo-Jorge TC, et al. Pharmacological Inhibition of Transforming Growth Factor beta Signaling Decreases Infection and Prevents Heart Damage in Acute Chagas' Disease. Antimicrobial Agents and Chemotherapy. 2009 Nov;53(11):4694-701.

Menna-Barreto RFS, Goncalves RLS, Costa EM, Silva RSF, Pinto AV, Oliveira MF, et al. The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction. Free Radical Biology and Medicine. 2009 Sep;47(5):644-53.

2008

Menna-Barreto, RFS, Laranja, GAT, Silva, MCC, Coelho, MGP, Paes, MC, Oliveira, MM, Castro, SL 2008. Anti-Trypanosoma cruzi activity of Pterodon pubescens seed oil: geranylgeraniol as the major bioactive component. Parasitol Res 103: 111-117.

Oliveira GM, Medeiros MM, Batista WS, Santana, R, Araujo-Jorge TC, De Souza AP 2008. Applicability of charcoal use for the evaluation of intestinal motility in a murine model of Trypanosoma cruzi infection. Parasitol Res 102: 747-750.

Cardoso, J, Soares, MJ, Menna-Barreto, RFS, Bloas, RL, Sotomaior, V, Goldenberg, S, Krieger, MA 2008. Inhibition of proteasome activity blocks Trypanosoma cruzi growth and metacyclogenesis. Parasitol Res 103: 941-951.

Meuser-Batista M, Correa JR, Soares MJ, Henriques-Pons A 2008. Isolation of cardiac mast cells in experimental Trypanosoma cruzi infection. Tissue Cell 40: 309-316.

Cascabulho, CM, Menna-Barreto, RFS, Coutinho-Silva, R, Persechini, PM, Henriques-Pons A 2008. P2X7 modulatory web in Trypanosoma cruzi infection. Parasitol Res 103: 829-838.

Correa JR, Atella GC, Batista MM, Soares MJ 2008. Transferrin uptake in Trypanosoma cruzi is impaired by interference on cytostome-associated cytoskeleton elements and stability of membrane cholesterol, but not by obstruction of clathrin-dependent endocytosis. Exp Parasitol 119: 58-66.

Souza EM, Marcos Meuser Batista, Batista, DGJ, Duarte BB, Araujo-Jorge TC, Soeiro MN 2008. Trypanosoma cruzi: alpha-2-macroglobulin regulates host cell apoptosis induced by the parasite infection in vitro. Exp Parasitol 118: 331-337.

Medrano-Mercado N, Ugarte-Fernandez R, Butrón V, Uber-Busek S, Guerra HL, de Araujo-Jorge TC, Correa-Oliviera R 2008. Urban transmission of Chagas disease in Cochabamba, Bolivia. Mem Inst Oswaldo Cruz 103: 423-430.

Silva CF, Marcos Meuser Batista, Batista, DGJ, Souza EM, Silva PB, Oliveira GM, Meuser AS, Shareef AR , Boykin D W, Soeiro MNC 2008. In vitro and in vivo studies of the trypanocidal activity of a diarylthiophene diamidine against Trypanosoma cruzi. Antimicrob Agents Chemother 52: 3307-3314.

Araujo-Jorge TC, Waghabi MC, Soeiro MNC, Keramidas M, Bailly S, Feige JJ 2008. Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy. Cytokine Growth Factor Rev 19: 405-413.

Spiegel CN, Alves GG, Cardona TS, Melim LM, Luz MRMP, Araujo-Jorge TC, Henriques-Pons A 2008. Discovering the cell: an educational game about cell and molecular biology. J Biol Educ 43: 27-35.

Ballester-Gil LM, Stotz EN, Hasslocher-Moreno AM, Alves-de-Azevedo B, de Araujo-Jorge TC 2008. O saber do paciente chagásico sobre a sua doença: construção compartilhada de um instrumento para a pesquisa e teste de sua aplicabilidade. Ciência Saúde Coletiva 13: 2199-2214.

Grossman E, de Araujo-Jorge TC, de Araujo IS 2008. Reflexões sobre os objetos e os ambientes físicos de ensino e pesquisa em saúde. Ciênc Saúde Coletiva 13: 2269-2277.

Waizbort R, de la Rocque LR 2008. Um replicador em movimento: aproximações entre a poética narrativa de Borges e o programa de pesquisa dos memes. Hist cienc saude-Manguinhos 15: 183-195.

Korenblum E, Sebástian, GV, Paiva MM, Coutinho CMLM, Magalhães FCM, Peyton, BM, Seldin L 2008. Action of antimicrobial substances produced by different oil reservoir Bacillus strains against biofilm formation. Appl Microbiol Biotechnol 79: 97-103.

Salomão K, Pereira PRS, Campos LC, Borba CM, Cabello PH, Marcucci MC, Castro SL 2008. Brazilian propolis: correlation between chemical composition and antimicrobial activity. Evid Based Complement Alternat Med 5: 317-324.

da Silva EN, Jr, Menna-Barreto, RFS, Pinto, MDCF, Silva RS, Teixeira, DV, Souza MCBV, de Simone, CA, Castro SL, Ferreira, VF, Pinto, AV 2008. Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi. Eur J Med Chem 43: 1774-1780.

Bani CB, Lagrota-Candido, J, Pinheiro, DF, Leite, PE, Salimena, MC, Henriques-Pons, A, Quirico-Santos, T 2008. Pattern of metalloprotease activity and myofiber regeneration in skeletal muscles of mdx mice. Muscle Nerve 37: 583-592.

Carvalho SA, Lopes FAS, Salomão K, Romeiro NC, Wardell SM, Castro SL, Silva EF, Fraga CA 2008. Studies toward the structural optimization of new brazilizone-related trypanocidal 1,3,4-thiadiazole-2-arylhydrazone derivatives. Bioorgan Med Chem 16: 413-421.

Silva Junior EN, Souza MCBV, Fernandes MC, Menna-Barreto RFS, Pinto MCFR, Lopes FA, Simone CA, Andrade CK, Pinto AV, Ferreira VF, Castro SL 2008. Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones. Bioorgan Med Chem 16: 5030-5038.

2007

Aguiar AL, Martins CJ, M Meuser-Batista, Carvalho VF, Barreto EO, E Silva PM, Corte-Real S, Baetas da Cruz W 2007. A case of keratoacanthoma centrifugum marginatum with a curious mast cell accumulation at tumour sites. J Eur Acad Dermatol Venereol 21: 392-435.

Carvalho A, Menna-Barreto RFS, Romeiro N, Castro SL, Boechat N 2007. Design, synthesis and activity against Trypanosoma cruzi of azaheterocyclic analogues of megazol. Med Chem Res 3: 460-465.

Cardona TS, Spiegel CN, Alves GG, Ducommun J, Henriques-Pons A, Araujo-Jorge TC 2007. Introducing DNA concepts to swiss high school students based on a Brazilian educational game. Biochem Mol Biol Edu 35: 416-421.

Machado GM, Leon LL, Castro SL 2007. Activity of Brazilian and Bulgarian propolis against different species of Leishmania. Mem Inst Oswaldo Cruz 102: 73-77.

Soeiro MNC, Souza EM, Boykin DW 2007. Anti-parasitic activity of aromatic diamidines and their patented literature. Expert Opin Ther Pat 12: 235-240.

Santoro GF, das Graças Cardoso M, Guimarães LG, Salgado AP, Menna-Barreto RF, Soares MJ 2007. Effect of oregano (Origanum vulgare L.) and thyme (Thymus vulgaris L.) essential oils on Trypanosoma cruzi (Protozoa: Kinetoplastida) growth and ultrastructure. Parasitol Res 100: 783-790.

Souza EM, Oliveira GM, Soeiro MN 2007. Electrocardiographic Findings in Acutely and Chronically T. cruzi-infected Mice Treated by a Phenyl-Substituted Analogue of Furamidine DB569. J Drug Target 2: 61-69.

Menna-Barreto RFS, Correa JR, Pinto AV, Soares MJ, Castro SL 2007. Mitochondrial disruption and DNA fragmentation in Trypanosoma cruzi induced by naphthoimidazoles synthesized from beta-lapachone. Parasitol Res 101: 895-905.

Santoro GF, Cardoso M, Mendonça L, Soares MJ 2007. Trypanosoma cruzi: activity of essential oils from Achillea millefolium L., Syzygium aromaticum L. and Ocimum basilicum L. on epimastigotes and trypomastigotes. Exp Parasitol 116: 283-290.

Adade CM, Castro SL, Soares MJ 2007. Ultrastructural localization of Trypanosoma cruzi lysosomes by aryl sulphatase cytochemistry. Micron 38: 252-256.

Silva CF, Batista MM, Mota RA, Souza EM, Stephens CE, Som P, Boykin DW, Soeiro MNC 2007. Activity of "reversed" diamidines against Trypanosoma cruzi in vitro. Biochem Pharmacol 73: 1939-1946.

Correa JR, Atella G, Menna-Barreto RFS, Soares MJ 2007. Clathrin in Trypanosoma cruzi: in silico gene identification, isolation, and localization of protein expression sites. J Eukaryot Microbiol 54: 297-302.

Adade CM, Figueiredo RC, Castro SL, Soares MJ 2007. Effect of L-leucine methyl ester on growth and ultrastructure of Trypanosoma cruzi. Acta Trop 101: 67-79.

Silva CF, Marcos Meuser Batista, Souza EM, Meirelles MNL, Stephens CE, Som P, Boykin DW, Soeiro MNC 2007. Cellular effects of reversed amidines on Trypanosoma cruzi. Antimicrob Agents Chemother 51: 3803-3809.

Oliveira GM, Diniz RL, Batista WS, Batista MM, Bani CB, Araújo-Jorge TC, Henriques-Pons A 2007. Fas Ligand-Dependent Inflammatory Regulation in Acute Myocarditis Induced by Trypanosoma cruzi Infection.. Am J Pathol 171: 79-86.

Nguyen DD, Maillard MH, Cotta-de-Almeida V, Mizoguchi E, Klein C, Fuss I, Nagler C, Mizoguchi A, Bhan AK, Snapper SB 2007. Lymphocyte-Dependent and Th2 Cytokine-Associated Colitis in Mice Deficient in Wiskott-Aldrich Syndrome Protein. Gastroenterology 133: 1188-1197.

Waghabi MC, Keramidas M, Calvet CM, Meuser M, Soeiro MNC, Mendonça-Lima L, Araujo-Jorge TC, Feige JJ, Bailly S 2007. SB-431542, a transforming growth factor beta inhibitor, impairs Trypanosoma cruzi infection in cardiomyocytes and parasite. Antimicrob Agents Chemother 51: 2905-2910.

Maillard MH, Cotta-de-Almeida V, Takeshima F, Nguyen DD, Michetti P, Nagler C, Bhan AK, Snapper SB 2007. The Wiskott-aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. J Exp Med 204: 381-391.

Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung Ul, Xavier R, Alt FW, Snapper SB 2007. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci USA 104: 15424-15429.

2006

Souza EM, Menna-Barreto RFS, Araújo-Jorge TC, Kumar A, Hu Q, Boykin DW, Soeiro MNC 2006. Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi. Parasitology 133: 75-79.

Paulino N, Teixeira C, Martins R, Scremin A, Dirsch VM, Vollmar AM, Abreu SR, de Castro SL, Marcucci MC 2006. Evaluation of the analgesic and anti-inflammatory effects of a Brazilian green propolis. Planta Med 72: 899-906.

Dantas AP, Salomão K, Barbosa HS, Castro SL 2006. The effect of Bulgarian propolis against Trypanosoma cruzi and during its interaction with host cells. Mem Inst Oswaldo Cruz 101: 207-211.

Dantas AP, Olivieri BP, Gomes FH, de Castro SL 2006. Treatment of Trypanosoma cruzi-infected mice with propolis promotes changes in the immune response. J Ethnopharmacol 103: 187-193.

Olivieri BP, Souza AP, Cotta-de-Almeida V, de Castro SL, Araújo-Jorge TC 2006. Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice. Exp Parasitol 114: 228-234.

Santa-Rita RM, Barbosa HS, Castro SL 2006. Ultrastructural analysis of edelfosine-treated trypomastigotes and amastigotes of Trypanosoma cruzi. Parasitol Res 100: 187-190.

Meis J, Mendes-da-Cruz DA, Farias-de-Oliveira DAF, Corrêa-de-Santana EC, Pinto-Mariz F, Cotta-de-Almeida V, Bonomo A, Savino W 2006. Atrophy of mesenteric lymph nodes in experimental Chagas´ disease: differential role of Fas/Fas-L and TNFRI/TNF pathways. Microbes Infect 8: 221-231.

Silva RS, Costa EM, Trindade UL, Teixeira DV, Pinto MC, Santos GL, Malta VR, de Simone AC, Pinto AV, de Castro SL 2006. Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi. Eur J Med Chem 41: 526-530.

Souza EM, Oliveira GM, Boykin DW, Kumar A, Hu Q, Soeiro MNC 2006. Trypanocidal activity of the phenyl-substituted analogue of furamidine DB569 against Trypanosoma cruzi infection in vivo. J Antimicrob Chemother 58: 610-614.

Batista, DGJ, Silva CF, Mota RA, Costa LC, Meirelles MNL, Meuser-Batista M, Soeiro MNC 2006. Trypanosoma cruzi modulates the expression of Rabs and alters the endocytosis in mouse cardiomyocytes in vitro. J Histochem Cytochem 54: 605-614.

Mendes-da-Cruz DA, Silva JS, Cotta-de-Almeida V, Savino W 2006. Altered thymocyte migration during experimental acute Trypanosoma cruzi infection: combined role of fibronectin and the chemokines CXCL12 and CCL4. Eur J Immunol 36: 1486-1493.

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